| # | # | Title | Airdate
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| 440 | 1 | Show 440 | September 4, 1995
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| 441 | 2 | Show 441 | September 5, 1995
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| 442 | 3 | Show 442 | September 6, 1995
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| 443 | 4 | Show 443 | September 7, 1995
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| 444 | 5 | Show 444 | September 8, 1995
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| 445 | 6 | Show 445 | September 11, 1995
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| 446 | 7 | Show 446 | September 12, 1995
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| 447 | 8 | Show 447 | September 13, 1995
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| 448 | 9 | Show 448 | September 14, 1995
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| 449 | 10 | Show 449 | September 15, 1995
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| 450 | 11 | Show 450 | September 18, 1995
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| 451 | 12 | Show 451 | September 19, 1995
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| 452 | 13 | Show 452 | September 20, 1995
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| 453 | 14 | Show 453 | September 21, 1995
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| 454 | 15 | Show 454 | September 22, 1995
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| 455 | 16 | Show 455 | September 25, 1995
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| 456 | 17 | Show 456 | September 26, 1995
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| 457 | 18 | Show 457 | September 27, 1995
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| 458 | 19 | Show 458 | September 28, 1995
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| 459 | 20 | Show 459 | September 29, 1995
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| 460 | 21 | Show 460 | October 2, 1995
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| 461 | 22 | Show 461 | October 3, 1995
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| 462 | 23 | Show 462 | October 4, 1995
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| 463 | 24 | Show 463 | October 5, 1995
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| 464 | 25 | Show 464 Helen Hunt; Ben Bradlee; Blues Traveler | October 6, 1995
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| 465 | 26 | Show 465 | October 16, 1995
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| 466 | 27 | Show 466 | October 17, 1995
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| 467 | 28 | Show 467 | October 18, 1995
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| 468 | 29 | Show 468 | October 19, 1995
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| 469 | 30 | Show 469 | October 20, 1995
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| 470 | 31 | Show 470 | October 23, 1995
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| 471 | 32 | Show 471 | October 24, 1995
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| 472 | 33 | Show 472 | October 25, 1995
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| 473 | 34 | Show 473 | October 26, 1995
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| 474 | 35 | Show 474 | October 27, 1995
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| 475 | 36 | Show 475 | October 30, 1995
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| 476 | 37 | Show 476 | October 31, 1995
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| 477 | 38 | Show 477 | November 1, 1995
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| 478 | 39 | Show 478 | November 2, 1995
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| 479 | 40 | Show 479 | November 3, 1995
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| 480 | 41 | Show 480 Danny DeVito; Brett Butler; John Michael Montgomery | November 6, 1995
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| 481 | 42 | Show 481 | November 7, 1995
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| 482 | 43 | Show 482 | November 8, 1995
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| 483 | 44 | Show 483 | November 9, 1995
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| 484 | 45 | Show 484 Jerry Seinfeld; David Duchovney; Bonnie Raitt and Bryan Adams | November 10, 1995
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| 485 | 46 | Show 485 | November 13, 1995
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| 486 | 47 | Show 486 | November 14, 1995
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| 487 | 48 | Show 487 | November 15, 1995
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| 488 | 49 | Show 488 | November 16, 1995
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| 489 | 50 | Show 489 | November 17, 1995
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| 490 | 51 | Show 490 | November 20, 1995
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| 491 | 52 | Show 491 | November 21, 1995
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| 492 | 53 | Show 492 | November 22, 1995
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| 493 | 54 | Show 493 | November 23, 1995
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| 494 | 55 | Show 494 | November 24, 1995
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| 495 | 56 | Show 495 | November 27, 1995
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| 496 | 57 | Show 496 | November 28, 1995
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| 497 | 58 | Show 497 | November 29, 1995
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| 498 | 59 | Show 498 | November 30, 1995
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| 499 | 60 | Show 499 | December 1, 1995
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| 500 | 61 | Show 500 Bob Hoskins; Martha Stewart; Al Green | December 11, 1995
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| 501 | 62 | Show 501 Jean Claude Van Damme; Kirstin Dunst; Michael Bolton | December 12, 1995
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| 502 | 63 | Show 502 Martin Short; Bev Tanner; Dave Matthews Band | December 13, 1995
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| 503 | 64 | Show 503 Harrison Ford; Bonnie Hunt; Bruce Springsteen | December 14, 1995
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| 504 | 65 | Show 504 Greg Kinnear; Janeane Garofalo; White Zombie | December 15, 1995
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| 505 | 66 | Show 505 Kathie Lee Gifford; Aaron Neville | December 18, 1995
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| 506 | 67 | Show 506 Jack Lemmon; Natalie Merchant | December 19, 1995
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| 507 | 68 | Show 507 Miss Howard Stern; Melissa Etheridge | December 20, 1995
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| 508 | 69 | Show 508 Geena Davis; Goo Goo Dolls | December 21, 1995
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| 509 | 70 | Show 509 Rosie O'Donnell; Mike Judge; Darlene Love | December 22, 1995
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| 510 | 71 | Show 510 Stupid Human Tricks; Julianna Marguiles; Del Amitri | December 26, 1995
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| 511 | 72 | Show 511 Mandy Patinkin; Terry Gilliam | December 27, 1995
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| 512 | 73 | Show 512 Robin Williams; Lauren Hutton; Chris Isaak | December 28, 1995
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| 513 | 74 | Show 513 Susan Sarandon; Drew Carey | December 29, 1995
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| 514 | 75 | Show 514 Lisa Kudrow; Art Donovan; Blues Traveler | January 2, 1996
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| 515 | 76 | Show 515 Chevy Chase; Marv Albert; Bruce Hornsby | January 3, 1996
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| 516 | 77 | Show 516 Tom Brokaw; Greg Fitzsimmons; Faith Hill | January 4, 1996
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| 517 | 78 | Show 517 Denis Leary; Bridget Hall; Toad the Wet Sprocket | January 5, 1996
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| 518 | 79 | Show 518 Sam Neill; Itzhak Perlman | January 8, 1996
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| 519 | 80 | Show 519 Pauly Shore; Ashley Judd | January 9, 1996
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| 520 | 81 | Show 520 Sandra Bullock; Marlon Wayans; Laurence Tai and New York Philharmonic members | January 10, 1996
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| 521 | 82 | Show 521 Jason Alexander; Elisabeth Shue | January 11, 1996
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| 522 | 83 | Show 522 Tim Robbins; Justin Wilson; Martina McBride | January 12, 1996
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| 523 | 84 | Show 523 David Brenner; B.B. King with John Popper | January 22, 1996
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| 524 | 85 | Show 524 Mia Farrow; Martin Scorcese; Brandy | January 23, 1996
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| 525 | 86 | Show 525 Don Rickles; Mary Stuart Masterson; Joe Ely and Todd Snider | January 24, 1996
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| 526 | 87 | Show 526 Matt Dillon; Reggie Miller; Pam Tillis | January 25, 1996
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| 527 | 88 | Show 527 Conan O'Brian; Mira Sorvino; Seven Mary Three | January 26, 1996
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| 528 | 89 | Show 528 Richard Simmons; Christine Lahti; Nanci Griffith & The Crickets | January 29, 1996
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| 529 | 90 | Show 529 Jay Thomas; Larry Brown | January 30, 1996
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| 530 | 91 | Show 530 Elle MacPherson; David Spade; D'Angelo | January 31, 1996
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| 531 | 92 | Show 531 Alec Baldwin; Dwight Yoakam; Natalie Portman | February 1, 1996
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| 532 | 93 | Show 532 Cybill Sheperd; Al Franken; Sati Achath | February 2, 1996
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| 533 | 94 | Show 533 Jack Hanna; Tammy Faye Messner; Aimee Mann | February 5, 1996
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| 534 | 95 | Show 534 Joan Collins; Robert Downey, Jr.; Jean Louisa Kelly | February 6, 1996
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| 535 | 96 | Show 535 Chuck Norris; Samantha Mathis | February 7, 1996
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| 536 | 97 | Show 536 Stupid Pet Tricks; Ray Liotta; Soul Asylum | February 8, 1996
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| 537 | 98 | Show 537 Uma Thurman; Norm MacDonald; Ramones | February 9, 1996
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| 538 | 99 | Show 538 Chris Farley; Gin Blossoms; Joe & Mary Graziano | February 12, 1996
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| 539 | 100 | Show 539 Adam Sandler; Jackie Chan; Red Hot Chili Peppers | February 13, 1996
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| 540 | 101 | Show 540 Siskel & Ebert; Neil Diamond; Brandy, Westminster Kennel Show "Best in Show" | February 14, 1996
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| 541 | 102 | Show 541 Tom Arnold; Joan Allen; Lenny Kravitz | February 15, 1996
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| 542 | 103 | Show 542 Teri Hatcher; Jon Stewart | February 16, 1996
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| 543 | 104 | Show 543 Kathie Lee Gifford; Gillian Anderson; Cecilia Bartoli | February 19, 1996
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| 544 | 105 | Show 544 Julia Roberts; James Brown | February 20, 1996
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| 545 | 106 | Show 545 Larry King; Wynonna | February 21, 1996
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| 546 | 107 | Show 546 Joan Lunden; Cheri Oteri; Lou Reed | February 22, 1996
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| 547 | 108 | Show 547 Kid Inventors; Sherry Stringfield; Don Henley | February 23, 1996
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| 548 | 109 | Show 548 Fran Drescher; Shania Twain; George Miller | February 26, 1996
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| 549 | 110 | Show 549 Dennis Hopper; Dave Chapelle; Pete Droge | February 27, 1996
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| 550 | 111 | Show 550 Susan Sarandon; Rob Schneider; Mike Dahm | February 28, 1996
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| 551 | 112 | Show 551 Kelsey Grammer; Victoria Abril; The Allman Brothers | February 29, 1996
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| 552 | 113 | Show 552 Robin Williams; Patsy Kensit; Spacehog | March 1, 1996
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| 553 | 114 | Show 553 Sarah Jessica Parker; Treat Williams; Cowboy Junkies | March 4, 1996
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| 554 | 115 | Show 554 Nathan Lane; Steven Wright; Jann Arden | March 5, 1996
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| 555 | 116 | Show 555 Stupid Human Tricks; Mira Sorvino; k.d. lang | March 6, 1996
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| 556 | 117 | Show 556 Dan Rather; Bonnie Hunt; The Tony Rich Project | March 7, 1996
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| 557 | 118 | Show 557 Dana Carvey; Riverdance | March 8, 1996
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| 558 | 119 | Show 558 Ricki Lake; William Shatner; Ray Romano | March 18, 1996
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| 559 | 120 | Show 559 Mandy Patinkin; Téa Leoni; Collective Soul | March 19, 1996
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| 560 | 121 | Show 560 Barbara Walters; Halle Berry; Ray Charles | March 20, 1996
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| 561 | 122 | Show 561 Phil Hartman; Rose Hamburger; The Band | March 26, 1996
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| 562 | 123 | Show 562 George Foreman; Naomi Campbell; Tim McGraw | March 27, 1996
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| 563 | 124 | Show 563 Don Johnson; Michelle Kwan; No Doubt | March 28, 1996
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| 564 | 125 | Show 564 Nick Turturro; Jenny McCarthy; Stone Temple Pilots | March 29, 1996
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| 565 | 126 | Show 565 Mary Tyler Moore; Anna Paquin; Mark Knopfler | April 1, 1996
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| 566 | 127 | Show 566 Bill Cosby; Anfernee Hardaway; Ray Wold | April 2, 1996
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| 567 | 128 | Show 567 Elle MacPherson; Hank Azaria; Cassandra Wilson | April 3, 1996
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| 568 | 129 | Show 568 Bill Maher; Michael Lomanaco; Jackson Browne | April 4, 1996
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| 569 | 130 | Show 569 David Hyde Pierce; Scott Thompson; Pulp | April 5, 1996
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| 570 | 131 | Show 570 Robert Duvall; Amy Brenneman; Tori Amos | April 8, 1996
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| 571 | 132 | Show 571 Tony Danza; Lucy Lawless; R. Kelly | April 9, 1996
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| 572 | 133 | Show 572 Dan Aykroyd; Louis C.K.; Sting | April 10, 1996
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| 573 | 134 | Show 573 Luciano Pavarotti & Michael Bolton; David Schwimmer; Cynthia Rowley | April 11, 1996
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| 574 | 135 | Show 574 Tom Brokaw; Blue; Rosanne Cash | April 12, 1996
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| 575 | 136 | Show 575 Joan Lunden; Nick Faldo; Jewel | April 22, 1996
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| 576 | 137 | Show 576 Mia Farrow; Janeane Garofalo; Hootie & the Blowfish | April 23, 1996
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| 577 | 138 | Show 577 Samuel L. Jackson; Jeff Altman; Los Lobos | April 24, 1996
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| 578 | 139 | Show 578 Hyper Kids Tell Jokes; Chazz Palminteri; Celine Dion | April 25, 1996
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| 579 | 140 | Show 579 Dana Carvey; Robin Quivers; Afghan Wigs | April 26, 1996
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| 580 | 141 | Show 580 Regis Philbin; Dave's Mom; Peter Berg | April 29, 1996
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| 581 | 142 | Show 581 Barbara Walters; Anthony Clark; Van Morrison | April 30, 1996
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| 582 | 143 | Show 582 Jeff Goldblum; James Carville; Brooks & Dunn | May 1, 1996
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| 583 | 144 | Show 583 John Malkovich; Jake Johannsen; Pete Townshend | May 2, 1996
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| 584 | 145 | Show 584 Rosie O'Donnell; Gwyneth Paltrow; Everclear | May 3, 1996
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| 585 | 146 | Show 585 Tom Hanks; Steve Young | May 6, 1996
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| 586 | 147 | Show 586 Paul Reiser; Jane Seymour; Keanu Reeves & Dogstar | May 7, 1996
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| 587 | 148 | Show 587 Stupid Pet Tricks; Dean Cain; Elvis Costello | May 8, 1996
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| 588 | 149 | Show 588 Eddie Murphy; Paul Doherty; Green Day | May 9, 1996
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| 589 | 150 | Show 589 Hot Dog Don Johnson; Jeremiah Tower; Alice in Chains | May 10, 1996
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| 590 | 151 | Show 590 Anjelica Huston; Paul Hogan; Natalie Merchant | May 13, 1996
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| 591 | 152 | Show 591 Jon Stewart; Kirstin Dunst; Dog's Eye View | May 14, 1996
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| 592 | 153 | Show 592 Jeff Foxworthy; Flyball Dogs; Joan Osborne | May 15, 1996
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| 593 | 154 | Show 593 Walter Cronkite; Harry Hill; Spin Doctors | May 16, 1996
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| 594 | 155 | Show 594 Helen Hunt; Dave Matthews Band | May 17, 1996
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| 595 | 156 | Show 595 Fran Drescher; Brian Regan; Joan Jett | May 20, 1996
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| 596 | 157 | Show 596 John Goodman; Norm MacDonald; Patty Loveless | May 21, 1996
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| 597 | 158 | Show 597 Stupid Human Tricks; Brett Butler; Al Green | May 22, 1996
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| 598 | 159 | Show 598 Leslie Nielsen; Daphne Zuniga; Bring in Da Funk | May 23, 1996
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| 599 | 160 | Show 599 Kid Inventors; Dennis Quaid; Seven Mary Three | May 24, 1996
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| 600 | 161 | Show 600 Martin Short; Jimmy Vassar; Bryan Adams | June 3, 1996
|
| 601 | 162 | Show 601 Nathan Lane; Daisy Fuentes; Mitch Fantel | June 4, 1996
|
| 602 | 163 | Show 602 Diana Ross; George Wallace | June 5, 1996
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| 603 | 164 | Show 603 Matthew Broderick; Kim Delaney; The cast of "Rent" | June 6, 1996
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| 604 | 165 | Show 604 Rosie O'Donnell; Heather Matarazzo; Cracker | June 7, 1996
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| 605 | 166 | Show 605 Siskel & Ebert; Andrew Shue; Dana Gould | June 10, 1996
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| 606 | 167 | Show 606 Dennis Franz; Joe Queenan; Gloria Estefan | June 11, 1996
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| 607 | 168 | Show 607 Ben Stiller; Liv Tyler; Douglas Rodriguez | June 12, 1996
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| 608 | 169 | Show 608 Danny Glover; Bobby Maley; Joey Kola | June 13, 1996
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| 609 | 170 | Show 609 Kelsey Grammar; Amber Valletta; Ozzy Osborne | June 14, 1996
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| 610 | 171 | Show 610 Vanessa Williams; Jonathan Silverman; Lucile Treganowan | June 17, 1996
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| 611 | 172 | Show 611 Sarah Jessica Parker; Marv Albert; Lyle Lovett | June 18, 1996
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| 612 | 173 | Show 612 James Caan; Julie White; Patti Smith | June 19, 1996
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| 613 | 174 | Show 613 Pauly Shore; Gena Lee Nolin; Vince Gill | June 20, 1996
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| 614 | 175 | Show 614 John Travolta; John Sayles; The Presidents of the United States of America | June 21, 1996
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| 615 | 176 | Show 615 Conan O'Brian; Eleanor Mondale; Blues Traveler | June 24, 1996
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| 616 | 177 | Show 616 Bruce Willis; Christine Wilson; Jimmy Buffett | June 25, 1996
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| 617 | 178 | Show 617 Jerry Van Dyke; Luke Perry; Fugees | June 26, 1996
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| 618 | 179 | Show 618 Cher; Shaquille O'Neal | June 27, 1996
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| 619 | 180 | Show 619 Michael Keaton; Ving Rhames; Goo Goo Dolls | June 28, 1996
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| 620 | 181 | Show 620 Harry Connick, Jr.; Josie Bisset | July 1, 1996
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| 621 | 182 | Show 621 Will Smith; Demi Moore | July 2, 1996
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| 622 | 183 | Show 622 Jeff Goldblum; Jonathan Katz; George Clinton & the P-Funk All-Stars | July 3, 1996
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| 623 | 184 | Show 623 Kids Tell Jokes; Dan O'Brian; The Brian Setzer Orchestra | July 4, 1996
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| 624 | 185 | Show 624 Randy Quaid; Sheryl Swoopes; The Cure | July 5, 1996
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| 625 | 186 | Show 625 Scottie Pippen; Prince; George Miller | July 8, 1996
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| 626 | 187 | Show 626 Bill Pullman; JoAnn Ussery; Willie Nelson | July 9, 1996
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| 627 | 188 | Show 627 Jack Hanna; Brent Spiner; Charlie Watts | July 10, 1996
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| 628 | 189 | Show 628 Meg Ryan; Shaolin Monks; Garbage | July 11, 1996
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| 629 | 190 | Show 629 Bill Murray; MaliVai Washington; The Wallflowers | July 12, 1996
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| 630 | 191 | Show 630 Margaret Colin; Lou Diamond Phillips; Wali Collins | July 15, 1996
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| 631 | 192 | Show 631 Laurence Fishburne; Lea Thompson; Me'Shell Ndegeocello | July 16, 1996
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| 632 | 193 | Show 632 Michael J. Fox; Shelly Moquin; Travis Tritt and Marty Stuart | July 17, 1996
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| 633 | 194 | Show 633 Andie MacDowell; Bob Woodward; Paul Westerberg | July 18, 1996
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| 634 | 195 | Show 634 David Duchovny; Jackie Joyner-Kersee; Sponge | July 19, 1996
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| 635 | 196 | Show 635 Danny DeVito; Amy VanDyken; Hootie & the Blowfish | August 5, 1996
|
| 636 | 197 | Show 636 Rhea Perlman; Dot Richardson; Reggie McFadden | August 6, 1996
|
| 637 | 198 | Show 637 Michael Johnson; Tom Arnold; Tracy Chapman | August 7, 1996
|
| 638 | 199 | Show 638 Dennis Miller; Mia Hamm; ButtHole Surfers | August 8, 1996
|
| 639 | 200 | Show 639 Dennis Hopper; Cheech Marin; Sex Pistols | August 9, 1996
|
| 640 | 201 | Show 640 Richard Simmons; Jerry O'Connell; Lionel Richie | August 12, 1996
|
| 641 | 202 | Show 641 Kevin Pollak; Diane Lane; Randy Travis | August 13, 1996
|
| 642 | 203 | Show 642 Ellen Barkin; Jackie Chan; Patti Rothberg | August 14, 1996
|
| 643 | 204 | Show 643 Dwight Gooden; Tom Selleck; George Jones | August 15, 1996
|
| 644 | 205 | Show 644 Mike Wallace; Tom Dolan; Dave Attell | August 16, 1996
|
| 645 | 206 | Show 645 Marilu Henner; Alex Rodriguez; J.R. Havlen | August 19, 1996
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| 646 | 207 | Show 646 Dennis Rodman; Susan Molinari; Neville Brothers | August 20, 1996
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| 647 | 208 | Show 647 Angie Everhart; Mario Van Peebles; Beach Boys | August 21, 1996
|
| 648 | 209 | Show 648 James Carville; Ed Burns; Melissa Etheridge | August 22, 1996
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| 649 | 210 | Show 649 Nathan Lane; Mara Wilson; Cast of "A Funny Thing Happened on the Way to the Forum" | August 23, 1996
|