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Flight is the twenty-second episode of the first season of Prison Break.
Starring: Dominic Purcell (Lincoln Burrows), Wentworth Miller (Michael Scofield), Robin Tunney (Veronica Donovan), Amaury Nolasco (Fernando Sucre), Marshall Allman (L.J. Burrows (credit only)), Wade Williams (Captain Brad Bellick), Paul Adelstein (Special Agent Paul Kellerman), Robert Knepper (Theodore "T-Bag" Bagwell), Rockmond Dunbar (Benjamin "C-Note" Franklin)
Guest Starring: Muse Watson (Charles Westmoreland), Peter Stormare (John Abruzzi), Michelle Forbes (Samantha Brinker), John Heard (Governor Frank Tancredi), Lane Garrison (David "Tweener" Apolskis), Silas Weir Mitchell (Charles "Haywire" Patoshik), Joseph Nunez (Manche Sanchez), John Billingsley (Terrence Steadman), Frank Grillo (Nick Savrinn)
Co-Starring: Christian Stolte (C.O. Stolte), Phillip Edward Van Lear (C.O. Patterson), Mac Brandt (C.O. Mack), Mark Morettini (C.O. #3), Javon Johnson (C.O. JJ), DuShon Brown (Nurse Katie), Jennifer Joan Taylor (Becky), Rich Komenich (Maggio), Kurt Naebig (C.O. Ray), Lester Kevin Senor (C.O. Kevin), David Alan Anderson (Orderly), TJ Jagodowski (Pilot), Doug James (Air Strip Controller), James Farruggio (Secret Service Agent at Press Conference), Coby Goss (Special Investigator), Steve Haggard (Sweats), Reese Madigan (Secret Service Man at Hotel), James Leaming (Agent In Charge at Hotel), Brian McCaskill (Reporter), Ilyssa Fradin (Female Reporter), Robin Robinson (TV Reporter), Craig Spidle (District Judge), Greg Sandquist (Cop #3 at Sara's), Patrick Clear (Deadly Solution Man #1), Raymond L. Chapman (Deadly Solution Man #2), Sam Zerante (Farmer), Samantha Scarpelli (Bike Girl)
Michael and the escape team must run for their lives as Warden Pope, Captain Bellick and the police attempt to track them down. Veronica arrives in Blackfoot, Montana to find the key evidence that can prove Lincoln's innocence. Caroline Reynolds finds herself no longer part of The Company's plans. Sara's part in the escape may cost her more than she knows.
- Caroline Reynolds is speculated to have assassinated the President of the United States. After the president's death, she is subsequently sworn in as the 46th president.
- Sara Tancredi overdosed on morphine. The police bursted into her apartment with an emergency warrant for accessory to the escape and found her unconscious on her couch.
- Haywire pilfered a bicycle and rode off into the unknown after being abandoned by the escape team.
- Tweener hid himself in a horse trailer that was heading off to St. Louis after Michael forced him to leave the team.