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A Change Is Gonna Come is the first episode of the fourth season of Grey's Anatomy, and the sixty-second episode overall.

Starring: Ellen Pompeo (Dr. Meredith Grey), Sandra Oh (Dr. Cristina Yang), Katherine Heigl (Dr. Isobel "Izzie" Stevens), Justin Chambers (Dr. Alex Karev), T.R. Knight (Dr. George O'Malley), Chandra Wilson (Dr. Miranda Bailey), James Pickens, Jr. (Dr. Richard Webber), Sara Ramirez (Dr. Callie Torres-O'Malley), Eric Dane (Dr. Mark Sloan), Chyler Leigh (Dr. Alexis "Lexie" Grey)

And: Patrick Dempsey (Dr. Derek Shepherd)

Guest Starring: Mark Pellegrino (Chris), Sandra Thigpen (Clara), Stephanie Childers (Nancy), Steven M. Porter (Joey)

Co-Starring: ...

Contents 1 Plot Overview 2 Notes 3 Arc Advancement 3.1 Happenings 3.2 Characters 3.3 Referbacks 4 Trivia 4.1 The Show 4.2 Behind the Scenes 4.3 Allusions and References 4.4 Memorable Moments 5 Quotes

[edit] Plot Overview

[edit] Notes

[edit] Arc Advancement

[edit] Happenings

[edit] Characters

[edit] Referbacks

[edit] Trivia

[edit] The Show

[edit] Behind the Scenes

[edit] Allusions and References

[edit] Memorable Moments

[edit] Quotes