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Safe is the sixteenth episode of the second season of House, M.D., and the thirty-eighth episode overall.
Starring: Hugh Laurie (Dr. Gregory House), Lisa Edelstein (Dr. Lisa Cuddy), Omar Epps (Dr. Eric Foreman), Robert Sean Leonard (Dr. James Wilson), Jennifer Morrison (Dr. Allison Cameron), Jesse Spencer (Dr. Robert Chase)
A teenaged girl with a heart transplant (Michelle Trachtenberg) has a violent allergic reaction despite being kept in a clean room by her overprotective mother. Meanwhile, House plays pranks on Wilson, but he claims he wants Wilson to stay as his roommate.
- Graphic Content Warning: This episode originally aired with a graphic content advisory.