House, M.D./Safe

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Season 2, Episode 16
Airdate April 4, 2006
Written by Peter Blake
Directed by Felix Alcala
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House, M.D.Season Two
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Safe is the sixteenth episode of the second season of House, M.D., and the thirty-eighth episode overall.

Starring: Hugh Laurie (Dr. Gregory House), Lisa Edelstein (Dr. Lisa Cuddy), Omar Epps (Dr. Eric Foreman), Robert Sean Leonard (Dr. James Wilson), Jennifer Morrison (Dr. Allison Cameron), Jesse Spencer (Dr. Robert Chase)

Guest Starring: Michelle Trachtenberg (Melinda Bardach), Mel Harris (Barbara Bardach), Jake McDorman (Dan), Lance Guest (Lewis Bardach)


Plot Overview

A teenaged girl with a heart transplant (Michelle Trachtenberg) has a violent allergic reaction despite being kept in a clean room by her overprotective mother. Meanwhile, House plays pranks on Wilson, but he claims he wants Wilson to stay as his roommate.


Arc Advancement





The Show

  • Graphic Content Warning: This episode originally aired with a graphic content advisory.

Behind the Scenes

Allusions and References

Memorable Moments