Grey's Anatomy/How Do I Live

How Do I Live
Season 21, Episode 18
Airdate	May 15, 2025
Written by	Meg Marinis
Directed by	Debbie Allen
Stream
← 21x17 Love You Like a Love Song	— N/A
Grey's Anatomy — Season Twenty-One

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How Do I Live is the eighteenth episode of the twenty-first season of Grey's Anatomy, and the four hundred forty-eighth episode overall.

Starring: Ellen Pompeo (Dr. Meredith Grey (voice)), Chandra Wilson (Dr. Miranda Bailey), James Pickens, Jr. (Dr. Richard Webber), Kevin McKidd (Dr. Owen Hunt), Caterina Scorsone (Dr. Amelia Shepherd), Camilla Luddington (Dr. Jo Karev), Jason George (Dr. Ben Warren), Kim Raver (Dr. Teddy Altman), Chris Carmack (Dr. Atticus Lincoln), Anthony Hill (Dr. Winston Ndugu), Alexis Floyd (Dr. Simone Griffin), Harry Shum Jr. (Dr. Daniel "Blue" Kwan), Adelaide Kane (Dr. Jules Millin), Niko Terho (Dr. Lucas Adams)

Guest Starring: Debbie Allen (Dr. Catherine Fox), Piper Perabo (Jenna Gatlin), Natalie Morales (Dr. Monica Beltran), Floriana Lima (Nora Young), Andy Bean (Aaron Gatlin), Sophia Kopera (Dylan Gatlin), Trevor Jackson (), Fareed Ward (Captain Bruno), Jacqueline Mazarella (Sarah)

Co-Starring: Payton Silver (Dr. Knox), Fran Nichols (Nurse Karen), Charleigh Jordan-Ortega (Miles Young), Bronson Arrivillaga (Max Young), Hannah Hurst (Lucy Young), Scarlette Cosio (Emily Young)

Plot Overview

While the interns are excited to transition to second-year residency, an ordinary day at Grey Sloan takes an unexpected turn when a medical emergency unfolds in the operating room, endangering lives inside the hospital.